1.AbioBundle Glass Tank Bioreactor

Applitech is deeply engaged in the field of biopharmaceuticals, and with nearly 20 years of experience in the bioreactor industry, we have independently designed and developed the AbioBundle series of glass tank bioreactors. This series of reactors can be used for microbial, fungal, plant cell, insect cell, mammalian cell and stem cell cultures, supporting high-density, aerobic and anaerobic fermentation, and protein expression research; the culture volume covers 50mL-16L, and it can realize batch, flow-addition, perfusion and continuous cultures, which is perfectly suited for research and development, pilot plant, and small-scale production work, and helps the process research and development of vaccines, antibodies, and cell/gene therapies.

1.1 AbioBundle M-Series Glass Tank Bioreactors

The AbioBundle M-Series glass tank bioreactors feature the M-Control embedded controller, a compact controller that facilitates the creation of up to 32 parallel culture systems for rapid experiments. The M-Control can be used for both cell culture and microbiology, allowing for quick configuration switching from microbiology to cell culture and easy control of the operation from a web browser or mobile device.The M-Control also comes in a wide range of color choices for personalization and to make your lab stand out from the rest.

M-Control

Features:

● Parallel control of the culture with independent monitoring of each reactor

● Up to 32 m-Control controllers form a network of parallel reactors.

● Easy operation control via web browser or mobile device (data can be stored and monitored without software)

● Cooling by peltier cooling system, no need to prepare cold water

● Small footprint, less than 1m2 for a 4-tank system.

● Online automatic detection of control parameters: PH, temperature, DO, agitation, level, foam, etc.

● Modular design, which can be easily changed to suit different applications and change the process control strategy

● Proprietary algorithms for precise control of process parameters

Supports up to 4 Watson marlow variable speed pumps with individual Prime buttons for each pump

● Supports up to 4 gas mass flow meters (MFC)

Supports commercially available electrodes and is compatible with smart electrodes.

● Total Gas control

● Ventilation system with 1 overlay and 2 sparger connections as standard, available with different orifice sizes and shapes of sparger

● A special breathing light that identifies the system's operating status.

● Connects to external devices such as cell density modules, fluorescent pH/dissolved oxygen electrodes, balances and other equipment.

● AbioPIMS LITE software comes standard.

● Can be configured to support tanks up to 15L.

● Remote monitoring and alarms can be realized

Size & Model

1.2 AbioBundle E-Series Glass Tank Bioreactors

AbioBundle E-series glass tank bioreactors use e-Control embedded controller or industrial computer version e Dual -Control, classic BenchTop design, colorful touch screen, intuitive operator interface, easy to operate, powerful, flexible configuration, easy to operate, easy to upgrade and expand. It is the best choice to carry out animal cell culture and microbial fermentation R&D projects. It can be flexibly configured according to the user's needs, and can be selected as single-control, dual-control or four-control mode, and supports 1/2/3/5/7/15/20L single-wall or jacketed glass tanks, and each tank can be operated independently in case of dual-control or four-control.

E-Control

e Dual -Control

Features:

● Modular design: various functional modules can be added or subtracted according to customer's application requirements.

● No welded parts on the tank top, all metal parts are made of 316L stainless steel, the stainless steel parts not in contact with the culture liquid are mirror-polished, and the stainless steel parts in contact with the culture liquid are electropolished, which is easy to clean.

● Borosilicate glass tanks with good shock resistance, corrosion resistance, smooth surface for easy cleaning and optimal transparency for visual monitoring of the incubation process, glass tanks withstand pressures of -1~0.5 barg.

● AbioBundle E series bioreactor adopts single control e-Control and dual control e Dual-Control (supports four controls).

● Single 12" and Dual 13.3" color touch screen interface for easy observation and operation.

● e-Control built-in 32G memory card, up to 20 weeks of data storage; eDual-Control built-in 256G data storage space, no need to worry about data loss.

● Three levels of password protection, allowing up to 23 operator accounts to be used simultaneously

● New WebUI function, you can set up and control the reactor through the web page.

● Optional Biomass Cell Density Module for on-line measurement of cell density and feedback replenishment.

● Stirring system: servo motor and mechanical seal stirring components, magnetic coupling stirring components can be upgraded.

● Enhanced gas selection module, each gas can be switched between 1 Overlay and 2 Sparger 3-way.

● Each tank can be equipped with up to 6 MFCs.

● Charge control: support external balance and charge pump associated, PID control, to realize complex charge strategy.

● e-Control supports up to 4 constant-speed pumps, with optional variable-speed pumps; eDual-Control supports up to 4 Watson marlow variable-speed pumps per tank; each pump is equipped with an independent mechanical Prime button.

● Total Gas Flow function, to maintain a constant total gas flow during the incubation process, to avoid excessive shear damage to the cells

● AbioPIMS Lite software comes standard.

● Multiple tanks can be run simultaneously or independently of each other.

●Multiple tanks can be configured flexibly with different volumes and different configurations.

● Through the expansion of a controller can support four tanks, realize one control four

● Remote monitoring can be realized

● Remote alarm can be realized to notify the user by SMS, phone, Email or WeChat.

● According to the customer's needs to realize the advanced expansion of functions, such as complex replenishment, etc.

Size & Model

P-Control

Features:

● Touch-screen operation of the human-machine interface, the interface is intuitive, easy to operate

● PLC process control platform

● Industrial control platform: Siemens

● Industrial standard Fieldbus I/O design, easy to maintain and expand functionality.

● Unlimited scalability and flexibility, superior reliability

● Pilot and industrial applications, open platform - e.g. link to Pi data logging

● Compliance with ISAS88, GAMP, cGAMP, etc.

● Measurement and control parameters

＞ pH (double pH), Dissolved Oxygen (double DO), Temperature, Foam, Liquid Level, Agitation, Weighing, Biomass, Optical Density OD, etc.

＞ Each tank can be configured with up to 6 channels of gas (optional 6 MFC).

＞ Balance (up to 4 balances)

＞ 8 built-in variable speed pumps

● Simultaneous control of multiple bioreactors of different sizes to facilitate scale-up

● AbioPIMS LITE software comes standard.

● Remote monitoring can be realized

● Remote alarm can be realized to notify the user by SMS, phone, Email or WeChat.

● Advanced functions can be realized according to customer requirements, such as complex dosing, etc.

2. AppliSoftec Data Management Software

AppliSoftec is divided into two series, AbioPIMS and AbioExpert, and each series is divided into four versions, Lite/Standard/Advanced/GMP, according to different functions.The AbioPIMS series software supports AbioSUS disposable bioreactors, AbioWave swinging disposable bioreactors, AbioBundle M/E/P series glass tank bioreactors, and is compatible with Applikon my-Control/ez-Control/ez2-Control series bioreactors.

AbioExpert series software supports AbioBundle M/E/P series glass tank bioreactors, AbioPilot stainless steel bioreactors, and is compatible with Applikon my-Control/ez-Control/ez2-Control series of bioreactors, and can also collect data from online analytical equipment such as Nova/Kaiser.

AppliSoftec's full range of software will be continuously updated, and customers can upgrade the corresponding version free of charge.

Minimum System Requirements

2.1 AbioPIMS Bioprocess Information Management System

AbioPIMS (Process Information Management System) is a set of process information system based on process flow developed by Applitech, which can be applied in industrial biotechnology and biopharmaceutical industry.

AbioPIMS Monitoring Interface

Features:

• Data management and information sharing within the company and among its subsidiaries.
• Rapid and effective planning, preparation, execution, and evaluation in bioprocess development and production environments.
• Improve efficiency, increase cost-effectiveness, and reduce engineering costs.
• Compatible with mainstream bioreactors in the market, able to communicate with analytical equipment and execution equipment, and collect data from analytical equipment at the same time
• Password protection, event logging, audit trails, electronic signatures, and other 21 CFR Part 11 requirements.
• OPC Client for flexible device connectivity and improved control of critical process parameters
• Easy-to-use recipe design function for efficient information conversion

Recipe Design Function

Information Conversion Module

2.2 AbioExpert Bioprocess Information Management System

AbioExpert is a set of professional software developed by Applitech based on the application of stainless steel bioreactors and AbioPIMS synchronization, both of which are basically the same in terms of functionality and can be applied in industrial biotechnology and biopharmaceutical industry.

AbioExpert Monitoring Interface

Recipe Design Function