Applitech is deeply engaged in the field of biopharmaceuticals, and with nearly 20 years of experience in the bioreactor industry, we have independently designed and developed the AbioBundle series of glass tank bioreactors. This series of reactors can be used for microbial, fungal, plant cell, insect cell, mammalian cell and stem cell cultures, supporting high-density, aerobic and anaerobic fermentation, and protein expression research; the culture volume covers 50mL-16L, and it can realize batch, flow-addition, perfusion and continuous cultures, which is perfectly suited for research and development, pilot plant, and small-scale production work, and helps the process research and development of vaccines, antibodies, and cell/gene therapies.
1.AbioBundle
Glass Tank Bioreactor
Applitech is deeply engaged in the field of
biopharmaceuticals, and with nearly 20 years of experience in the bioreactor
industry, we have independently designed and developed the AbioBundle series of
glass tank bioreactors. This series of reactors can be used for microbial,
fungal, plant cell, insect cell, mammalian cell and stem cell cultures,
supporting high-density, aerobic and anaerobic fermentation, and protein
expression research; the culture volume covers 50mL-16L, and it can realize
batch, flow-addition, perfusion and continuous cultures, which is perfectly
suited for research and development, pilot plant, and small-scale production
work, and helps the process research and development of vaccines, antibodies,
and cell/gene therapies.
1.1
AbioBundle M-Series Glass Tank Bioreactors
The AbioBundle M-Series glass tank bioreactors feature the M-Control embedded controller, a compact controller that facilitates the creation of up to 32 parallel culture systems for rapid experiments. The M-Control can be used for both cell culture and microbiology, allowing for quick configuration switching from microbiology to cell culture and easy control of the operation from a web browser or mobile device.The M-Control also comes in a wide range of color choices for personalization and to make your lab stand out from the rest.
M-Control
Features:
● Parallel control of the culture with
independent monitoring of each reactor
● Up to 32 m-Control controllers form a
network of parallel reactors.
● Easy operation control via web browser or
mobile device (data can be stored and monitored without software)
● Cooling by peltier cooling system, no
need to prepare cold water
● Small footprint, less than 1m2 for a
4-tank system.
● Online automatic detection of control
parameters: PH, temperature, DO, agitation, level, foam, etc.
● Modular design, which can be easily
changed to suit different applications and change the process control strategy
● Proprietary algorithms for precise
control of process parameters
Supports up to 4 Watson marlow variable
speed pumps with individual Prime buttons for each pump
● Supports up to 4 gas mass flow meters (MFC)
Supports commercially available electrodes
and is compatible with smart electrodes.
● Total Gas control
● Ventilation system with 1 overlay and 2
sparger connections as standard, available with different orifice sizes and
shapes of sparger
● A special breathing light that identifies
the system's operating status.
● Connects to external devices such as cell
density modules, fluorescent pH/dissolved oxygen electrodes, balances and other
equipment.
● AbioPIMS LITE software comes standard.
● Can be configured to support tanks up to
15L.
● Remote monitoring and alarms can be realized
Size & Model
Model |
Working volume |
Tank type |
AbioBundle M 250ml |
50~200ml |
Single-wall |
AbioBundle M 500ml |
100~400ml |
Single-wall |
AbioBundle M 1L |
0.2~0.8L |
Single-wall |
AbioBundle M 2L |
0.5~1.7L |
Single-wall |
AbioBundle M 3L |
0.6~2.7L |
Single-wall |
1.2 AbioBundle E-Series Glass Tank Bioreactors
AbioBundle E-series glass tank bioreactors
use e-Control embedded controller or industrial computer version e Dual
-Control, classic BenchTop design, colorful touch screen, intuitive operator
interface, easy to operate, powerful, flexible configuration, easy to operate,
easy to upgrade and expand. It is the best choice to carry out animal cell
culture and microbial fermentation R&D projects. It can be flexibly
configured according to the user's needs, and can be selected as
single-control, dual-control or four-control mode, and supports
1/2/3/5/7/15/20L single-wall or jacketed glass tanks, and each tank can be
operated independently in case of dual-control or four-control.
Features:
● Modular design: various functional modules can be added or subtracted according to customer's application requirements.
● No welded parts on the tank top, all metal parts are made of 316L stainless steel, the stainless steel parts not in contact with the culture liquid are mirror-polished, and the stainless steel parts in contact with the culture liquid are electropolished, which is easy to clean.
● Borosilicate glass tanks with good shock resistance, corrosion resistance, smooth surface for easy cleaning and optimal transparency for visual monitoring of the incubation process, glass tanks withstand pressures of -1~0.5 barg.
● AbioBundle E series bioreactor adopts single control e-Control and dual control e Dual-Control (supports four controls).
● Single 12" and Dual 13.3" color touch screen interface for easy observation and operation.
● e-Control built-in 32G memory card, up to 20 weeks of data storage; eDual-Control built-in 256G data storage space, no need to worry about data loss.
● Three levels of password protection, allowing up to 23 operator accounts to be used simultaneously
● New WebUI function, you can set up and control the reactor through the web page.
● Optional Biomass Cell Density Module for on-line measurement of cell density and feedback replenishment.
● Stirring system: servo motor and mechanical seal stirring components, magnetic coupling stirring components can be upgraded.
● Enhanced gas selection module, each gas can be switched between 1 Overlay and 2 Sparger 3-way.
● Each tank can be equipped with up to 6 MFCs.
● Charge control: support external balance and charge pump associated, PID control, to realize complex charge strategy.
● e-Control supports up to 4 constant-speed pumps, with optional variable-speed pumps; eDual-Control supports up to 4 Watson marlow variable-speed pumps per tank; each pump is equipped with an independent mechanical Prime button.
● Total Gas Flow function, to maintain a constant total gas flow during the incubation process, to avoid excessive shear damage to the cells
● AbioPIMS Lite software comes standard.
● Multiple tanks can be run simultaneously or independently of each other.
●Multiple tanks can be configured flexibly with different volumes and different configurations.
● Through the expansion of a controller can support four tanks, realize one control four
● Remote monitoring can be realized
● Remote alarm can be realized to notify the user by SMS, phone, Email or WeChat.
● According to the customer's needs to realize the advanced expansion of functions, such as complex replenishment, etc.
Size & Model
Model |
Working volume |
Tank type |
AbioBundle E 1L |
0.2~0.8L |
Single-wall/jacketed |
AbioBundle E 2L |
0.5~1.7L |
Single-wall/jacketed |
AbioBundle E 3L |
0.6~2.7L |
Single-wall/jacketed |
AbioBundle E 5L |
0.9~3.4L |
Single-wall/jacketed |
AbioBundle E 7L |
1.5~5.2L |
Single-wall/jacketed |
AbioBundle E 15L |
3.0~12L |
Single-wall/jacketed |
AbioBundle E 20L |
3.0~16L |
Single-wall/jacketed |
1.3 AbioBundle P-Series Glass Tank Bioreactors
AbioBundle P-series glass tank bioreactors
use PLC-based p-Control controller, programmable control, scalable, GMP
compliant, can be used for production, with optional audit trail function,
single, dual or quad control modes, support 1/2/3/5/7/15/20L single-wall or
jacketed glass tanks, from laboratory, pilot to production scale It can be used
from laboratory, pilot to production scale to maximize the time and cost
savings in the scale-up process. p-Control can control multiple bioreactors at the
same time, and can be applied to a variety of industry-standard controller
systems.
P-Control
Features:
● Touch-screen operation of the
human-machine interface, the interface is intuitive, easy to operate
● PLC process control platform
● Industrial control platform: Siemens
● Industrial standard Fieldbus I/O design,
easy to maintain and expand functionality.
● Unlimited scalability and flexibility,
superior reliability
● Pilot and industrial applications, open
platform - e.g. link to Pi data logging
● Compliance with ISAS88, GAMP, cGAMP, etc.
● Measurement and control parameters
> pH (double pH), Dissolved Oxygen (double
DO), Temperature, Foam, Liquid Level, Agitation, Weighing, Biomass, Optical
Density OD, etc.
> Each tank can be configured with up to 6
channels of gas (optional 6 MFC).
> Balance (up to 4 balances)
> 8 built-in variable speed pumps
● Simultaneous control of multiple
bioreactors of different sizes to facilitate scale-up
● AbioPIMS LITE software comes standard.
● Remote monitoring can be realized
● Remote alarm can be realized to notify
the user by SMS, phone, Email or WeChat.
● Advanced functions can be realized
according to customer requirements, such as complex dosing, etc.
2. AppliSoftec Data Management Software
AppliSoftec is divided into two series,
AbioPIMS and AbioExpert, and each series is divided into four versions,
Lite/Standard/Advanced/GMP, according to different functions.The AbioPIMS
series software supports AbioSUS disposable bioreactors, AbioWave swinging
disposable bioreactors, AbioBundle M/E/P series glass tank bioreactors, and is
compatible with Applikon my-Control/ez-Control/ez2-Control series bioreactors.
AbioExpert series software supports
AbioBundle M/E/P series glass tank bioreactors, AbioPilot stainless steel
bioreactors, and is compatible with Applikon my-Control/ez-Control/ez2-Control
series of bioreactors, and can also collect data from online analytical
equipment such as Nova/Kaiser.
AppliSoftec's full range of software will be continuously updated, and customers can upgrade the corresponding version free of charge.
Minimum System Requirements
Processor/clock rate |
Multi-core processor 2.5 GHz |
RAM on board |
8 GB (16 GB recommended) |
Hard disk space |
256 GB |
Optical drive |
DVD-ROM drive |
Network adapter |
1 + LAN adapter, RJ- 45,100 Mbit |
Graphics card |
DirectX 10,1 GB RAM (recommended) |
Screen resolution |
1920 x 1080, 100% scaled and aligned |
Monitor |
23.8-inch display |
Operating system |
Microsoft Windows 10 (64-bit) |
Running components |
NET Framework 4.0 / NET Framework 5.0 /
.NET Core 3.1 |
Other Software |
Microsoft Excel (2013 recommended) / SQL
Server 2014 / MongoDB |
2.1 AbioPIMS Bioprocess Information Management System
AbioPIMS (Process Information Management System) is a set of process information system based on process flow developed by Applitech, which can be applied in industrial biotechnology and biopharmaceutical industry.
AbioPIMS Monitoring Interface
Features:
Recipe Design Function
Information Conversion Module
2.2 AbioExpert Bioprocess Information Management System
AbioExpert is a set of professional software developed by Applitech based on the application of stainless steel bioreactors and AbioPIMS synchronization, both of which are basically the same in terms of functionality and can be applied in industrial biotechnology and biopharmaceutical industry.