AbioPilot stainless steel bioreactor has a standard modular design that allows for rapid functional qualification, project design, and assembly for production. For pilot-scale stainless steel bioreactors below 300L, we provide standardized products to further simplify the design and production process and quickly respond to customer needs. The standardized products include 30/45/80/130/300L cell tanks and 30/45/75/140/270L fermenters. More than 300L or non-standard volume bioreactors are customized, designed and manufactured on demand.Custom build units can be supplied up to 20000 liter total volume. AbioPilot stainless steel reactors support cleaning-in-place (CIP) and sterilization-in-place (SIP).They are designed using CFD and 3D models in the design phase. From theory to process implementation, it was designed in accordance with the ASME BPE guidelines and met the GMP and GAMP validation requirements. A complete solution is provided from laboratory scale to production scale.

Feature

• 316L stainless steel, easy to clean mirro polished external finish
• Electropolished finish of all parts in contact with the culture (Ra < 0.4µm) to allow efficient CIP
• Open frame construction gives easy access for maintenance and operation
• Modular design allows easy adaptation to changing process demands
• GMP compliant design simplifies validation
• Compact design reduces floor space needed

Applications

• Mammalian cell, plant cell, insect cell, microbial and fungal culture
• Scale-up for production of vaccines, antibodies, and cell/gene therapies
• Batch, Fed-batch, Perfusion, and Continuous cultivation
• Suitable for pilot and commercial production work

AbioPilot Specifications 

AbioExpert® Process Information Management System

 AbioExpert is a suite of specialized software for industrial biotechnology and biopharmaceutical applications. AbioExpert series software supports AbioBundle M/E/P series glass tank bioreactors,AbioPilot stainless steel bioreactors, and can also collect data from Nova/Kaiser and other on-line analyzers.

AbioExpert family of software is compatible with the Applikon my-Control/ez-Control/ez2-control series of bioreactors. It is divided into four versions according to different functions: Lite/Standard/Advanced/GMP

Features

• Realize data management and information sharing within the whole company and among branches;
• Rapidly and efficiently meet bioprocess development and production needs;
• Improve efficiency, increase cost-effectiveness, and reduce engineering costs;
• Compatible with mainstream bioreactors on the market, able to communicate with analyzing and executing equipment and collect data from analyzing equipment at the same time.

Access management

With password protection, user group settings, define access rights, operation permissions

21 CFR Part 11

Multi-level security controls ,logged event logs, audit trails, and electronic signatures in accordance with 21 CFR Part 11 requirements

Configure

It has various ways to configure the data acquisition port, and the system specifies the data import template file for the data acquisition channel of the device.

①With multi-device access capability, device connection parameter configuration, connection control strategy

②Perfect alarm function configuration:able to customize alarm strategy and response strategy

OPC

Based on the OPC platform, the OPC Client provides flexible connectivity to devices and improve the control of key process parameters; 

UI

The intuitive configuration flow simplifies the usage and speeds up task startup. You can use the navigation to quickly access all configuration-related information. When monitoring, you can jump to each module such as unit, trend, alarm, sample, etc.

Data

Monitoring & Management Provide complete monitoring and history record storage functions, data recording with integrity and security, enabling fast, powerful and searchable high-quality data collection and management, Data and configuration information can be exported to generate reports; It has perfect traceability and query function of system log, alarm information and operation information;

CHART

Powerful chart tools - Trend window: View all relevant process parameters and configure online trends as required.

①According to the requirements, the chart can be zoomed in and out, moved, stretched, captured, curve style, time selection, parameters can be hidden or displayed, and individual charts can be added, edited or deleted as required;

②Allows comparison and tracking of all process data: 

Multiple historical batch data can be synchronously compared by process timeline

MONITOR

Quickly switch to any of the 16 monitoring units and view all related information, and customize the display of the monitoring modules on the screen; the monitoring window allows you to view and navigate to all menu information, such as batch operation, alarm settings, recipe control, real-time trending, and sample collection, etc.

CONTROL

The set values can be controlled individually or in batches;  

RECIPE: Easy-to-use recipe design

Provides easy-to-follow on-screen instructions that guide you through the configuration of a recipe from start to finish, and can be used to write advanced control strategies that automatically change setpoints based on incubation conditions and time. No programming skills are required; simply drag and drop logic blocks into place and configure conditional functions to generate branch, parallel, wait, loop, skip, and sequential logic;

CALCULATOR- Efficient data conversion

Calculation of important bioprocess parameters and non-directly measurable variables in the calculation module and logical connections in the formulation module.

Please note

Software Updates

All AbioExpert software will be updated continuously, and customers can upgrade the corresponding version for free.

Minimum System Requirements

Processor/clock rate: Multi-core processor 2.5 GHz

RAM: 8GB (16GB recommended) 

Hard disk space: 256 GB

Optical Drive: DVD-ROM drive

Network adapter: 1+ LAN adapter, RJ-45, 100 Mbit Graphics: DirectX10,1 GB RAM (recommended)

Screen resolution: 1920x1080, 100% zoom and alignment

Monitor: 23.8-inch monitor