Cell Filling System
Cell Filling System
Automatic Cell Filling System AbioFill V100
• Automated operation, easy to achieve large-scale cell filling
• Efficient and fast, easy to pack ~300 cells in 20 minutes Cryotubes
• Good consistency, filling volume accuracy error <5%
• Flexible configuration, filling capacity range is 250 μL-5 mL
• Comply with GMP requirements, audit trail, multi-level authority management
• Automated dispensing for cell bank construction of MCB and WCB
AbioFill
V100 is an automated system for filling screw-cap cryovials in GMP
laboratories. It creates higher quality cell bank by minimizing the time of
cells in cryopreservative before freezing, and maintains sample integrity by
handling cells gently with lower risk of contamination compared to manual
processing. It is ideal for create higher quality, consistency and viability of
WCB/MCB cell banks or filling for biologics.
Key Features & Benefits
•
Automated operation make High-Throughput cell filling easy
•
Efficient and fast, filling ~300 cryovials within 20 minutes
•
Excellent consistency, CV <5% of filling accuracy
•
Flexible configuration with filling volume ranging from 250 μL to 5 mL
•
Comply with GMP requirements, audit trail, multi-level authority management
•
Automated cell banking manufacture for MCB and WCB
Product Details
Cell filling process
Single-use disposable sterile consumables
Cross-contamination can be avoided by using single-use, aseptic filling consumables. The irradiated filling tube assembly is packaged in a double-bagged aseptic bag, provides reassurance on product integrity. The left side of the filling tube can be connected to shake tube, shake bottle, sterile wave bag, etc.
Easy to operate
The installation of the filling tube set is easy, just load and fix on the rack. Remove the needle sleeve which is used to ensure needle sterility for cell filling.
Fast, automated filling with great
consistency
Compared with manual processing, the automated filling system can remove the error from manual, fill the cryovials quickly and simply, and ~300 cryovials can be easily filled in 20 minutes.
The volume accuracy was tested by filling 500 μL, 1000 μL and 4000 μL respectively, the data shows volume accuracy error was <5%;
3 different concentrations of cells were filled into 24 cryovials, and the cell viability deviation was<2%, and the viable cell concentration deviation was <5%. The AbioFill V100 have excellent consistency, which is more conducive to the establishment of higher quality and consistent cell banks.
In addition, CHO cells and MSC cells were respectively filled into 24 cryovials, and after 24 hours of freezing, they were revived. the cell viability deviation was< 5%, and the viable cell concentration deviation was < 5%, and the total cell concentration deviation was < 5%. The quality of cells before and after filling and freezing is not affected, and a high-quality and uniform cell bank can be established, effectively solving the industrial problem of large-scale cell freezing.
CHO Cells
MSC Cells
Easy and intuitive software operation
▪ Customized Filling models: Select
the appropriate module, cryovial rack according to the cryovial type
▪ Multiple operation modes:
• "Decap
– Filling – recap" mode
•
"Filling Only" mode
• "Decap
only" mode
• "Recap
Only" mode
▪ Filling flow rate: fast filling,
350-800 μL/s can be selected, ~300 cryovials can be easily filled in 20 minutes.
▪ Filling volume range is from 250
μL to 5 mL with good consistency.
▪ Number of Fillling columns: the
cryovials can be loaded (4, 8, 12, 16, 20, 24 vials) in order, and columns can
be set accordingly
▪ Cumulative quantity and capacity: The software tracks the number and total capacity of Filled cryovials in real time.
Audit trail, User Management
AbioFill
V100 is GMP compatible with audit trail and multi-level authority management
functions:
•
Account and password login
•
Multi-level user management
• Audit trails
UV sterilization
Customized
UV sterilization lamp is optional, and it is controlled by software to
sterilize the filling module and the rack transfer unit.
Compatible with Various Cryovials
•
AbioFill V100 system is flexible and compatible with various Cryovials and the
relevant accessories can be individually customized
•
Filling volumes range: 250 μL-5 mL
•
AbioFill V100 comes with accessories including cryovial racks and decap/recap
module to accommodate the cryovial types selected.
• More brands of cryovial accessories can be customized.
Product Applications
• GMP cell banking;
• Strain banks for biopharma process development
and R&D;
• Strain banks for food industry, industrial biotech, and biofuels.
