AbioMixer Benchtop Mixing System

Conventional Systems

Conventional liquid preparation systems are primarily used for mixing or storage of buffers, culture media, intermediates, and semi-finished products during formulation processes. However, systems with working volumes typically exceeding 50L are often unable to meet the requirements of small-scale mixing in process development or manufacturing workflows.

The AbioMixer Benchtop Mixing System is used with pre-sterilized single-use magnetic stirring bags, ensuring complete isolation between the system and the external environment. Additionally, through the transparent bag and probe modules on the device, the status of the liquid and various parameters can be monitored at any time,integrating control, observation, and data storage in one system.

Features

• Modular design: in addition to standard stirring and weighing functions, optional modules can be added to meet diverse process requirements.
• Compatible with Haimore single-use mixing bags, eliminating cleaning and sterilization processes and enabling fast and efficient liquid preparation workflows.
• Full product line validated by computational fluid dynamics (CFD); optimized mixing strategy achieves an ultra-fast mixing time as low as 3 seconds.
• Interchangeable vessel design allows a single system to accommodate different container sizes, supporting flexible mixing applications.
• User access control matrix, audit trail, and data management functions comply with GMP and 21 CFR Part 11 requirements.

Computational Fluid Dynamics (CFD) simulation results

Application

Commercial manufacturing

For small-volume mixing requirements of buffer solutions and intermediate products in commercial production processes: Extends the scale of conventional mixing systems to 0.6L, addressing the data gap in the handling of small-volume solutions in conventional processes, while meeting GMP requirements for data integrity and audit trail.

Laboratory Scale

For the preparation of culture media, buffer solutions, and product mixing during the lab-scale research phase: Enhances data integrity during the project development cycle, reduces operator interference in condition-controlled experiments, and ensures consistency in mixing effectsacross different experimental batches.

Pilot Scale

During the pilot scale-up phase of process development, where mixing process parametersare critical: The process parameters provided bythe benchtop mixing system can serve as a reference for subsequent scale-up parameters, ensuring that every stirring coefficient and weight parameter is supported by data, providingtheoretical support for process scaling.

Optional Features

Temperature Detection Module

Real-time monitoring of system temperature via temperature sensing components. When used in combination with a temperature control jacket and TCU, the temperature of the process fluid can be monitored and regulated.

Temperature Control Module

Enables precise control of process fluid temperature through a temperature control jacket integrated with a TCU system.

pH Module

Real-time monitoring of the pH inside the system using a pH sensor.

Conductivity Module

Real-time monitoring of system pH using an in-line pH sensor.

Technical Specifications

Order Information