AbioWave - Rocking motion single use bioreactor 

The Rocking motion single use bioreactor AbioWave utilizes advanced wave motion technology to provide an efficient, controlled, and easily scaled-up culture environment for cell culture processes, mimicking the fluid mixing effect found in traditional stirred reactors while avoiding the mechanical shear and bubble introduction problems associated with traditional stirrers.

AbioWave uses self-developed disposable culture bags as culture vessels, eliminating the need for cleaning and sterilization and reducing the time and cost of cleaning operations.

AbioWave supports 10L, 25L, 50L total volume of disposable culture bags, culture volume covers 1~25L, can meet the different needs of R & D, pilot plant, production, seed expansion and other work.

The AbioWave is suitable for a wide range of cell culture applications, including mammalian cell culture, human stem cell culture, insect cell culture and plant cell culture. 

- Batch Cultures

- Fed-batch cultures

- Perfusion Cultures

- Adherent cell culture

Main Features

- AbioWave is powered with PLC control system which shows stable and reliable performance.

- γ-ray irradiation sterilization of disposable culture bags before use to reduce the risk of contamination and simplify the validation process.

-easy to replacea trays to match different culture volume requirements.

-Flexible configuration for maximum customization.

- Intuitive and easy-to-use operating system with OPC communication, compliant with FDA 21 CFR Part 11.

- Optional AbioPIMS software for real-time monitoring and advanced data management of multiple devices.

AbioWave Controller

- Using Siemens PLC S7-1500, high-performance PLC, safe and reliable.

-Using Net SCADA development interface, with OPC function, with hierarchical rights, Audit trail, compliant with FDA 21 CFR Part 11.

- 13.5-inch interface, touch screen, with a stylus for easy operation.

- Integrated with precise PID algorithm control for temperature, pH, DO, weight, etc.. User-defined cascade function, rich process mode options, and over-range alarm function.

- Three control modes: pH/DO mode, total gas flow mode and CO2 concentration mode are available for users to choose, which can meet the needs of different cultivation processes.

- Built-in SCADA software for real-time data recording and storage, which can monitor multiple devices and can realize advanced data operation such as data curve view, export and comparison.

AbioBag culture bag

AbioBag is made of 7 layers of composite co-extruded film, no animal-derived components, with a total thickness of 320um, with excellent strength and resistance to mechanical tension. 

The innermost layer of the bag is made of ULDPE (Ultra Low Density Polyethylene) which is in direct contact with the sample to ensure good biocompatibility and provide the necessary ductility.

The bags are sterile, non-pyrogenic, airtight, and comply with USP Class VI and ISO 10993 international biosafety standards, and are available with full material certification, and can be deeply customized to meet the needs of our customers.

AbioPIMS - Process Information Management System

AbioPIMS (Process Information Management System) is a set of process information system based on process flow and developed independently by Applitech, which can be applied to industrial biotechnology and biopharmaceutical industries.

AbioPIMS softwares supports AbioSUS disposable bioreactors, AbioWave disposable bioreactors, AbioBundle M/E/P series glass bioreactors, and is also compatible with Applikon my-Control/ez-control/ez2-control bioreactors.

Authorization

Password protection

User group management 

Definition of access rights

Operating authorization.

21 CFR Part 11 Compliance

Three user levels (operator, supervisor, and administrator) 

Event logs

Audit trails

Electronic signatures.

Configuration

With a variety of data acquisition port configuration, the system specifies the device data acquisition channel data import template file.

1 with multi-device access capabilities, device connection parameter configuration, connection control strategy.

2 perfect configuration of the alarm function, the ability to customize the alarm strategy and response strategy.

3 storage mode configuration, storage method, value display conversion, etc..

1 with multi-device access capabilities, device connection parameter configuration, connection control strategy

2 perfect alarm function configuration: highhigh/high/low/lowlowlow

Storage Configuration Mode: Equal Interval or based on Event

OPC

Based on the OPC platform, the OPC Client allows flexible connection of equipment and improved

control of critical process parameters.

UI

The intuitive configuration flow simplifies operation, speeds up task startup, provides quick access to all configuration-related information using navigation, and allows you to jump between modules such as units, trends, alarms, samples, etc. during monitoring.

DATA - data monitoring and management

Provide complete monitoring and history data saving function, the saving mode can be periodic or based on change. Data recording with integrity and security, realize fast, powerful and searchable high-quality data collection and management. Data and configuration information can be exported to generate reports.

It has perfect traceability and query function of system log, alarm information and operation information.

CHART

Powerful Charting Tools - Trend Chart Window: View all relevant process parameters at a glance and configure online trends as required.

1Zoom in and out, move, stretch, intercept, curve style, time selection, hide or show parameters, add, edit or delete individual charts as required.

2 Allows comparison and tracking of all process data.

3 Allows comparison and tracking of all process data (up to 8 batches).

- Synchronized comparison of multiple historical batches of data, by process timeline.

- Synchronized comparison of current runtime data, by process timeline, with historical data

MONITOR

Quickly switch to any of the 24 monitoring units and view all relevant information, and customize the monitoring module display within the screen; the monitoring window allows you to view and navigate to all menu information, batch runs, alarm settings, recipe control, real-time trending, sample collection, and more. They eliminate the need to close process windows to find stored recipes or files.

CONTROL

Remote control setpoints

RECIPE - Simple and easy to use Recipe function

Provides easy-to-follow instructions on-screen that guide you through the configuration of a recipe from start to finish, and can be used to write advanced control strategies that automatically change setpoints based on culture conditions and time. No programming skills are required; simply drag and drop logic blocks into place, configure conditional functions, and generate branching, parallel, wait, loop, skip, and sequential logic.

CALCULATOR - Efficient information transformation

Calculation of important bioprocess parameters and non-directly measurable variables with the calculation module and logical connections in the formulation module.

Free Trial

The AbioPIMS family of software is free of charge for 60 days after the initial installation.

Software Updates

AbioPIMS series software will be updated continuously, and customers can upgrade the corresponding version free of charge.

Minimum System Requirements

Processor/clock rate:Multi-core processor 2.5GHz

RAM: 8GB (16GB recommended)

Hard disk space: 256 GB

Optical Drive:DVD-ROM drive

Network adapter: 1+ LAN adapter, RJ-45, 100 Mbit

Graphics card: DirectX 10, 1 GB RAM (recommended)

Screen resolution: 1920 x 1080, 100% zoom and alignment

Monitor: 23.8-inch monitor

Operating System: Microsoft Windows 10(64-bit)

Running components :. NET Framework4.0/NET

NET Framework5.0 / .NET Core 3.1

Other software:Microsoft Excel (2013 recommended) / SQL Server 2014 / MongoDB