AbioSUS single-use bioreactor consists of a stainless steel tank (integrated TCU temperature control unit), AbioControl IDS.S controller, and AbioBag culture bag. AbioSUS follow the design concepts of traditional stirred bioreactors, including specific aspect ratios and optimized paddle positions to ensure that the process conditions between AbioSUS and traditional stirred bioreactors are as close or consistent as possible, allowing users to quickly switch between R&D/production platforms. AbioSUS provides standard specifications such as 50/200/500/1000/2000L and can be customized on demand, covering the needs from process development(PD) to large-scale production, and can be widely used in antibodies, vaccines, cell therapy/gene therapy(CGT) and other fields of multi-process type of upstream cell culture.

AbioBag:

The culture bag is mounted on a fixed bracket and connected to AbioSUS to form a complete bioreactor. 7 layers of co-extruded film. Standard double-blade Marine mixing system. Double bottom sparger.

Load cell holder:

During the installation and transportation process or when not used for a long time, the holder can be directly stressed to avoid Load cell sensor damage. When the equipment is in use, the holder is removed and the sensor directly carries the tank, thus monitoring the weight of the culture solution. C6 grade weighing system.

Fixed bracket:

For fixing and mounting of the AbioBag, can be used to fix all kinds of filters, while hiding cable piping, beautifying appearance, Reduce exposure wear. Exhaust filter electric heating blanket. Servo mixing motor.

Door + Window：

Large area single door design for easy replacement of AbioBag, door panel with large transparent window and scale, easy to observe the inside of the culture bag. Double-layer jacket structure of door.

Sensor operating area:

After the AbioBag is installed and secured, various sensor port operate in this area. The operating area is modeled after that of stainless steel bioreactor, can ensure that the various sensors are fully exposed to the culture solution, at the same time avoid the sensor too close to the agitator accidental damage. AbioSUS supports both conventional and disposable pH/DO electrodes, as well as dual pH/DO electrodes.

AbioControl IDS.S controller

• The controller adopts modular design, flexible configuration, suitable for different application scenarios, and supports 50L to 2000L AbioSUS single-use bioreactors;

• Touch screen operation interface, with five levels of operation rights (View, Operator, Engineer, Supervisor, Administrator), through rights management, to ensure the controllability of the production process; With audit trail function, all operations are recorded in the log;

• Touch Screen with anti-touch and lock screen function, to protect the safety of the production process;

• The controller is equipped with multiple control loops such as temperature, stirring, pH and DO, which can display all process parameters and change process control strategy;

• Flexible cascade control loop can be switched according to different control requirements to achieve stable control of parameters, to ensure the stability and reproducibility of the experimental process;

• Strong scalability, can be connected to third-party equipment through 4-20mA or modbus, such as variable speed pump, MFC, balance and exhaust gas analyzer, support multiple control software interaction and data transmission;

• Flexible configuration, according to the different needs of customers, can be customized;

• The controller is equipped with 24V DC UPS power supply, to ensure the stable operation of the control detection system and the continuity of data recording;

• It is convenient and fast to switch the bottom sparger by software.

• Small size, small footprint, saving space of the controller.

Operation interface

AbioBag culture bag

AbioBag with 7 layers of composite co-extruded film, animal component free (ADCF),With a total thickness of 320um, it has excellent strength and mechanical tensile resistance. The innermost layer uses ultra-low density polyethylene (ULDPE) in direct contact with the sample, and ensures good biocompatibility and provides the necessary ductility. AbioBag is sterile, pyregen-free and good air tightness, meets USP Class VI and ISO 10993 international biosafety standards, provides complete material certification, and can be deeply customized according to customer needs.

AbioSUS single-use bioreactor features

Top motor drive, easy disassembly

Large area single door design, convenient loading bag

Tank and door body double-layer jacket water circulation, Simultaneous heating or cooling to improve overall temperature uniformity.

Double impeller mixing design, different volumes of mixing more uniform

Double bottom sparger design, 0.8mm open-pipe +150um micro-pipe, can be switched online to achieve a variety of ventilation strategies, can effectively improve KLa, pH control, reduce foam generation. The bottom sparger type and specifications can be customized.

Supports traditional and disposable pH/DO electrodes, and can support dual pH/DO electrodes at the same time.

The tank integrates TCU temperature control system, without external heating temperature control equipment, with TEC refrigeration anti-overtemperature function. The TCU is controlled by the IDS.S controller

C6 Grade load cell for accurate weighing

The performance of AbioSUS was confirmed by CFD method, the results showed that the bioreactor had good oxygen mass transfer capacity and mixing performance, and could provide low shear force and uniform heating, which could meet the needs of cell culture for growth environment.

AbioPIMS - Process Information Management System

AbioPIMS (Process Information Management System) is a set of process information system based on process flow and developed independently by Applitech, which can be applied to industrial biotechnology and biopharmaceutical industries.

AbioPIMS softwares supports AbioSUS disposable bioreactors, AbioWave disposable bioreactors, AbioBundle M/E/P series glass bioreactors, and is also compatible with Applikon my-Control/ez-control/ez2-control bioreactors.

Features

Realize data management and information sharing within the whole company and between each branch;.

Meet bioprocess development and production needs quickly and efficiently.

Improve work efficiency, increase cost-effectiveness and reduce engineering costs.

Compatible with the mainstream bioreactors on the market, able to communicate with analytical equipment and actuator equipment, and collect data from analytical equipment at the same time.

Authorization

Password protection

User group management 

Definition of access rights

Operating authorization.

21 CFR Part 11

Three user levels (operator, supervisor, and administrator) 

Event logs

Audit trails

Electronic signatures.

Configuration

With a variety of data acquisition port configuration, the system specifies the device data acquisition channel data import template file.

1. with multi-device access capabilities, device connection parameter configuration, connection control strategy.

2. perfect configuration of the alarm function, the ability to customize the alarm strategy and response strategy.

3. storage mode configuration, storage method, value display conversion, etc..

OPC

Based on the OPC platform, the OPC Client allows flexible connection of equipment and improved

control of critical process parameters.

UI

The intuitive configuration flow simplifies operation, speeds up task startup, provides quick access to all configuration-related information using navigation, and allows you to jump between modules such as units, trends, alarms, samples, etc. during monitoring.

DATA - data monitoring and management

Provide complete monitoring and history data saving function, the saving mode can be periodic or based on change. Data recording with integrity and security, realize fast, powerful and searchable high-quality data collection and management. Data and configuration information can be exported to generate reports.

It has perfect traceability and query function of system log, alarm information and operation information.

CHART

Powerful Charting Tools - Trend Chart Window: View all relevant process parameters at a glance and configure online trends as required.

1. Zoom in and out, move, stretch, intercept, curve style, time selection, hide or show parameters, add, edit or delete individual charts as required.

2. Allows comparison and tracking of all process data (up to 8 batches).

-Synchronized comparison of multiple historical batches of data by process timeline.

-Synchronized comparison of current runtime data by process timeline with historical data.

MONITOR

Quickly switch to any of the 24 monitoring units and view all relevant information, and customize the monitoring module display within the screen; the monitoring window allows you to view and navigate to all menu information, batch runs, alarm settings, recipe control, real-time trending, sample collection, and more.

CONTROL

Setpoints can be remote controlled individually or in batches.

 

RECIPE - Simple and easy to use Recipe function

Provides easy-to-follow instructions on-screen that guide you through the configuration of a recipe from start to finish, and can be used to write advanced control strategies that automatically change setpoints based on culture conditions and time. No programming skills are required; simply drag and drop logic blocks into place, configure conditional functions, and generate branching, parallel, wait, loop, skip, and sequential logic.

CALCULATOR - Efficient information transformation

Calculation of important bioprocess parameters and non-directly measurable variables with the calculation module and logical connections in the formulation module.

Free Trial

The AbioPIMS family of software is free of charge for 60 days after the initial installation.

Software Updates

AbioPIMS series software will be updated continuously, and customers can upgrade the corresponding version free of charge.

Minimum System Requirements

Processor/clock rate:Multi-core processor 2.5GHz

RAM: 8GB (16GB recommended)

Hard disk space: 256 GB

Optical Drive:DVD-ROM drive

Network adapter: 1+ LAN adapter, RJ-45, 100 Mbit

Graphics card: DirectX 10, 1 GB RAM (recommended)

Screen resolution: 1920 x 1080, 100% zoom and alignment

Monitor: 23.8-inch monitor

Operating System: Microsoft Windows 10(64-bit)

Running components :. NET Framework4.0/NET

NET Framework5.0 / .NET Core 3.1

Other software:Microsoft Excel (2013 recommended) / SQL Server 2014 / MongoDB