Review of CBioPC2024

• by Applitech
• 120

The 23rd China Biological Products Annual Conference (CBioPC2024) sponsored by China Vaccine Industry Association was held in Guangzhou from May 16 to 18.

The conference set up the main venue around the cutting-edge technology of biological medicine, and set up 11 sub-venues such as vaccine quality and R & D, recombinant therapeutic biological products, immune cells, stem cells and gene therapy, clinical research of innovative biological products, vaccination, quality safety of blood products, clinical application of blood products, international cooperation ecological seminar on vaccines, biopharmaceutical engineering technology, application of AI in the field of biological medicine, and digital transformation of biological medicine.

At this conference, Applitech will bring many equipment to booth H21, attracting professionals to stop and visit, and have in-depth discussions and exchanges with us. Thank you to all our customers and partners who came to our booth. Let us work together for the future.

As a high-tech enterprise integrating design, R & D, production, sales and service, Applitech comprehensively demonstrated its technology and product advantages in the field of biological medicine at this exhibition, and attracted many industry experts and teachers to visit the booth for exchange and business negotiation.

 product 

Cell Bank Manufacturing and Development

Cytena Single-Cell Printer

1. Patented inkjet single-cell printing sorting technology, soft sorting

2.  Sorting speed block: 1 ~ 2min/96 well plate, 8min/384 well

3. Sweep speed: ~ 5min

4. Provide double guarantee of nozzle pattern and clone pattern, single cell rate>99.99%
   

5. Provide monoclonal reports to track and verify monoclonal compliance with FDA requirements
   

6. Single-use cartridges to avoid cross-contamination

7. Fluorescent dyes can be used to screen cell lines and gene editing cells for their activity.
   

8. Suitable for various cell lines, successfully sorted CHO, HEK293, iPSC, MSC, MDCK, Hela, RBC precursors and other cells
   

9. It is widely used in the fields of antibody, vaccine, gene and cell therapy. Monoclonal cell line screening, cell seed bank, single cell PCR/sequencing, single cell proteomics, etc.
   

High-throughput automated cell counter Countleader FL 2000

1. Automatic staining technology
2. Analyze 24 samples in less than 13 minutes
3. Only 30 μL of cell sample required
4. Calibration, maintenance and service free
5. Customizable PDF reports
6. 21 CFR part11 compliant

Automatic Cell Filling System AbioFill V100

1. Automated operation, easy to achieve large-batch cell filling
   

2. Fast, easy to fill ~300 cryotubes in 20 min

3. Good consistency, sub-packaging volume accuracy error <5%

4. Soft filling, difference in cell viability before and after filling <2%

5. Flexible configuration with fill volumes ranging from 250 μL to 5 mL

6. GMP compliance, audit trail, multi-level authority management

7. Automated Filling for Cell Bank Establishment for MCB and WCB

8. Successfully filled CHO, MSC, iPSC, HEK293 cells

Cell Culture and Microbial Fermentation

Glass tank bioreactor

1. AbioBundle M-Series：Adopt m-Control controller, classic mini design, small size, spacesaving, realize multi-link parallel control, support 250ml/500ml/1/2/3L glass tanks.
2. AbioBundle E-Series: Adopt e-Control or e Dual-Control controller, classic BenchTop design, colorful touch screen, intuitive operation interface, easy to operate, flexible configuration according to user needs, single control, dual-control or four control modes is optional, support 1/2/3/5/7/15/20L single-wall or jacketed glass tanks.
3. AbioBundle P-Series: Adopt PLC-based p-Control controller with strong expandability, single control, dual-control or four control modes is optional, support 1/2/3/5/7/15/20L singlewall or jacketed glass tanks.
4. AbioBundle D-Series: Adopt DeltaV-based d-Control controller, support 250ml/500ml/1/2/3/5/7/15/20L single-walled or jacketed glass tanks. On-demand monitoring and control with commercially available controllers supporting OPC, Modbus, Profibus DP protocols

AbioWave Rocking Motion Single Use Bioreactor

1. AbioWave is powered with PLC control system which shows stable and reliable performance.
2. γ-ray irradiation sterilization of disposable culture bags before use to reduce the risk of contamination and simplify the validation process.
3. easy to replacea trays to match different culture volume requirements.
4. Flexible configuration for maximum customization.
5. Intuitive and easy-to-use operating system with OPC communication, compliant with FDA 21 CFR Part 11.
6. Optional AbioPIMS software for real-time monitoring and advanced data management of multiple devices.

AppliReact AbioSUS single-use bioreactor

1. Opening and closing door, easy to load bag
2. Water circulation in full jacket realizing thermal control in door and vessel to improve the consistency of micro-environment
3. Novel dual-impeller for different scale cell culture
4. Uses the latest probe sensor technology in single-use or autoclavable probes
5. Integrated TCU (Thermo Circulator Unit), no need for extra heating device
6. Dual-sparger with gas outlet selection. Improve kLa, optimize pH control, and reduce the formation of bubbles
7. Audit trial, 21 CFR part 11 compliant. Support analog in and out. Integrated to SCADA software by OPC connectivity

single-use application fluid managment

Aseptic Sealer A100

1.Automatic design, 1/4"~1-3/8" more comprehensive use, suitable for TPE tubes with a range of 1/4" to 1-3/8" OD.

2.7" touch screen design with user-friendly interface.

3.One-click start, easy to operate.

4.Strong compatibility, suitable for TPE tube sealing in different states.

5.More efficient, whole process and key parameters display.

6.Quick aseptic sealing and cut centerline alert to facilitate disconnection.

7.FDA 21 CFR PART11 compliant with authority management and audit tracking capabilities.

Aseptic Welder 100 

1.Self-check to ensure operation, automatic welding and process display.

2.Supports 1/4" to 1" OD with different tubes supports available, automatic identification of tube specifications.

3.Heating to 400℃ for sterilization and heat source removal, ensure aseptic welding process.

4.Preset Saint Gobain C-Flex® 374 TPE tube parameters and support parameter settings for different brands of TPE tubes.

5.Rotary welding technology, one-click start, quick operation.

6.Sterile testing, bacterial challenge testing, tensile strength testing, flow rate testing, insoluble particles, and pressure testing documents available.

7.FDA 21 CFR PART11 compliant with authority management and audit tracking capabilities. 

Process Analysis

BioProfile Flex2 Automated Cell Culture Analyzer

1. Up to 16 important cell culture parameters can be analyzed simultaneously: chemistry/body, CDV, osmolality;
2. 11 chemical/biological parameters using maintenance-free sensor card technology;
3. All 16 important parameters can be measured with only 265μL sample.
4. The analysis time is only 2~ 4.5 minutes.
5. External sampling modules (ESM, OLS, Flownamics Seg-Flow, etc.) can be connected to realize automatic sampling analysis;
6. OPC connectivity to reactor controllers, data historians, LIMS systems, and plant management systems;
7. Meet GMP requirements and comply with 21 CFR Part 11.

Kaiser RamanRxn2TM analyzer

1. Insensitive to water
2. One probe for multiple measurements
3. Measures key process and quality parameters
4. Proven model transferability to process development and manufacturing scales
5. Scalable from lab to pilot to cGMP
6. In-line installation reduces risk of contamination
7. Low maintenance, easy to use
8. Intuitive, embedded control software via touchscreen or remote interface

Chromatography

Chromatography system

1. The unique design of four pumps and two channels, the flow rate range of 1~100 mL/min and 10~1000 mL/min respectively, can simultaneously develop full test process to pilot cGMP production.
2. Automatic component collection based on pH, UV, conductivity.
3. Radial flow spectroscopy technique is used to support forward, reverse and bypass flow of samples. Unique automatic drain function and leakage monitoring function.
4. Simple and intuitive operation, automatic GMP report.